Select min or max values within one cell (delimited string)

I have a data frame where for each sample the columns can have multiple values, for example:

Gene       Pvalue1             Pvalue2              Pvalue3                  Beta
Ace    0.0381, ., 0.00357    0.01755, 0.001385    0.0037, NA , 0.039         -0.03,1,15
NOS          NA                  0.02              0.001, 0.00067              0.00009,25,30

I want to apply min() and max() for each gene's data (I have thousands of genes in total) in each column and get the smallest value for the pvalues but the largest value for columns such as the beta. So the output data would look like this:

Gene       Pvalue1             Pvalue2              Pvalue3                  Beta
Ace        0.00357              0.001385             0.0037                   15
NOS          NA                  0.02                0.00067                  30

I'm new to R and not sure if what I'm asking is possible, if there are multiple values in one cell are they viewed as strings?